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SyntellyApp
Here you will learn about the latest changes and new features of our platform. We are constantly working on improving the functionality to make your user experience as convenient and efficient as possible
Platform updates
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Solubility prediction
The new module allows you to predict the solubility of organic compounds in 18 solvents at various temperatures. You can set the temperature range from -30°C to +130°C and obtain a detailed graph of the temperature dependence of solubility, including the confidence interval.
Supported solvents: ethanol, methanol, isopropanol, ethyl acetate, acetone, n-propanol, n-butanol, acetonitrile, toluene, DMF, DMSO, chloroform, THF, dioxane, carbon tetrachloride, cyclohexane, hexane, and diethyl ether.
For each calculation, the model's Applicability Domain and standard deviation are displayed, which allows you to evaluate the reliability of the forecast.
Interface improvements and increased convenience
Step-by-step training – all modules of the platform have onboarding implemented, which helps new users quickly master the functionality. Interactive prompts will guide you through the main features of each tool.
Search history - support for text prompts and synonyms in addition to SMILES.
Molecular Editor — added:
  • Tooltips for all buttons and tools
  • Pop-up with a full list of keyboard shortcuts
  • Contextual help when working with complex functions
The context menu is optimized for convenience: the main buttons (feedback, notifications, and up) are kept visible, while the rest are moved to the "Advanced" menu.
SynMap — real-time display of the number of selected structures allows you to monitor the 1,000-structure limit during the work process.
Database Expansion
Compounds and literature
Integrated into the platform:
  • 11.6 million scientific articles
  • 1.6 million IUPAC names
  • 4.4 million synonyms (ID ChemDiv, CAS, and other identifiers)
Experimental data
New entries have been added for the following physical and chemical properties:
  • Boiling point (Boiling point)
  • Flash point (Flash point)
  • Melting point (Melting point)
  • Vapor Pressure (Vapor Pressure)
  • Water Solubility (Water Solubility)
  • Density (Density)
  • Refractive Index (Refractive Index)
And toxicological and environmental data:
  • Guinea pig oral LD50
  • Mouse oral LD50
  • Rat oral LD50
  • Blood-brain barrier permeability (LogBB)
  • Daphnia Magna LC50
  • Tetrahymena Pyriformis IGC50
Datasets
25 thematic datasets on metal complexes have been integrated, which can be useful for educational purposes and specialized research.
3 thematic datasets with molecules from ChemDiv have been added.
Favorites: personal data collections
The new "Favorites" section allows you to create your own collections for quick access to the materials you need. You can add the following to your favorites:
  • Chemical structures
  • Scientific articles or patents
  • Reactions
  • Spectra
The notification system informs you about the successful addition or deletion of objects. All selected materials are available in one place, which speeds up working with frequently used data.
PDF2SMILES: Improved Recognition Accuracy
The module for automatically extracting structures from documents has received significant improvements:
  • The accuracy of molecule detection has been increased to 90% with minimal false positives.
  • The correctness of recognition has been improved.
  • Filters have been added that remove incorrectly recognized molecules with gross errors and correct some recognition defects.

The interface has been improved by adding automatic highlighting of cards when you click on a molecule in the text, and new icons with tips for easier use.
The cost of synthesis: integrating Russian suppliers and new reactions
The key innovation is the integration of the largest Russian chemical suppliers. This is critical for working with limited access to international catalogs. Now you can:
  • Build a reaction tree based on the availability of reagents in Russia
  • See the cost of the entire synthesis and individual steps from Russian suppliers
  • Go directly to the supplier's website to place an order
This makes it much easier for Russian pharmaceutical companies, research institutes, and chemical enterprises to plan their synthesis, from forecasting to procurement.
The synthesis cost calculation module has undergone a major update. The database now contains 4 times more known reactions, significantly expanding the possibilities for synthesis planning.
In version 2.6, we have expanded the platform's capabilities by adding new tools for property prediction and synthesis planning. The integration of the solubility prediction module, updated synthesis costs with Russian suppliers, and a significant expansion of the database will help speed up your research and improve the accuracy of your predictions. The interface has been made even more user-friendly with new data handling capabilities and step-by-step training.
If you're already working with Syntelli, check out how the functionality has changed. If you're not familiar with the platform yet, now is the perfect time to start with the new onboarding.
20.11.2025
Syntelli 2.6: New Tools for Efficient Work
In version 2.5, we expanded the scope and depth of data, improved the interface, and carried out a major technical upgrade. These changes make the platform even more stable, accurate, and user-friendly.
Data Coverage and Management
  • Added 682 new entries on DMSO solubility — more experimental properties are now available.
  • The “Full Text” button now takes you directly to the source article or patent.
  • Increased dataset upload limits in trial access: 5,000 structures per operation within a single dataset and 50,000 structures per month — speeding up work with large data collections.
Literature Search
Added connections between structures and 7 million scientific articles. When viewing a molecule card, you can now see even more publications where it is mentioned and described.
Reaction Search
Expanded dropdown suggestions — now, as in structure search, both SMILES and synonyms are recognized. This makes search more convenient and consistent.
Tabular Analysis
  • Improved information displaying and added filtering by model applicability.
  • Experimental values are now visually highlighted and displayed as the most significant.
  • The SMILES column is now fixed and always visible.
Interface
  • Added error alerts in retrosynthesis and synthesis cost modules. The system now flags invalid SMILES or incorrect formats.
  • Enabled molecule highlighting via the context menu in Search and Datasets — a clearer and more visible way to select substances.
  • Optimized molecule pages for small screens — making it comfortable to work on compact devices.
  • Enabled direct navigation from structure comparison to a molecule card to view details.
  • Added cross-module navigation from the molecular editor via the context menu — making switching between different tasks faster.
  • Introduced a toggle to show or hide reaction conditions in bulk, saving screen space.
  • Switching between languages on the platformis now more intuitive and user-friendly.
User Feedback and Data Accuracy
Users can now report experimental data errors directly through the interface. In molecule cards, you can flag incorrect data, suggest corrections, and add source links, which helps improve data accuracy more quickly.
Already using Syntelly? Check out the new interface and features.
New to the platform? Now’s the perfect time to start — it’s faster and smarter than ever.
If you have any suggestions or comments on the platform, now is the time to share your thoughts. Email us at admin@syntelly.com.
Expanded Database and Improved Data Quality
  • Added 32,008 new data points for experimentally measured molecular properties.
  • Compiled a set of approximately 5,000 trusted molecules — compounds most frequently used by our users. Reliable experimental properties are being collected for this set.
  • Over 2 million chemical reactions have been imported into the system.
  • Corrected rounding errors and unit inconsistencies in molecular property data.
Enhanced Tabular Analysis and Data Export
The tabular analysis module has been significantly upgraded:
  • Introduced model applicability threshold settings for predicted properties, allowing users to filter out low-confidence results and ensure data reliability.
  • All results are now exportable in CSV and XLSX formats — ready for further analysis or inclusion in scientific reports.
  • The interface has been redesigned for better structure and clarity, making it easier and faster to locate relevant compounds across large datasets by property combinations.
Architectural and Interface Enhancements
  • Began the transition to TypeScript, increasing the reliability of the frontend and accelerating the debugging process.
  • Optimized the logic for dataset type selection, improving context-aware behavior across the platform.
  • Refreshed the visual design of the “Spectra prediction” and “Synthesis Cost” sections — data presentation is now cleaner and easier to read.
  • In the SMILES2IUPAC converter, users can now draw structures directly using the embedded editor, offering greater flexibility in molecule input.
  • Fixed visual glitches when navigating between molecule cards and pages.
Platform Registration and User Feedback
  • Improved the registration form by reducing the number of required fields and enhancing error handling — making the process faster and more intuitive.
  • Integrated a regular user feedback survey into the product. This will help us continuously gather insights and incorporate them into future updates.
Enhanced Data Export Options
Export options have been updated in all key system modules:
  • Improved PDF format for structure cards with all calculated parameters
  • Export of spectrum prediction results
  • Saving synthesis prediction results in PNG format These improvements simplify the integration of obtained results into further research processes.
Updated User Guide
The User Guide has been fully migrated to a new documentation platform, providing:
  • More intuitive navigation between sections and easier language switching
  • Faster keyword search across the documentation
  • Consistent and responsive display across various devices
Cintelli is starting to formulate a refinement plan for 2025. If you have any suggestions or comments on the platform, now is the time to share your thoughts. Email us at admin@syntelly.com.
  1. Quick structure transfer to other modules from the structure card has been implemented;
  2. Improved feedback form: added separate topics of appeals, as well as uploading files and images;
  3. Fixed rendering errors of structural formulas, and improved the quality and contrast of images;
  4. Split the synonyms block into “Titles” and “Database IDs” for easy search and browsing;
  5. SynMap module: added buttons to completely clear the map and stop generation, as well as the ability to view the generator settings after it is started.
Visual and logical refinements:
  1. Tabular analysis: You can now sort and filter structures within your own datasets by target property values before exporting;
  2. Datasets can be sorted by number of structures, by creation date and by name;
  3. The search bar has been integrated into the module: now it is possible to search both datasets and structures within each dataset;
  4. Added the ability to select an operator when loading a CSV file, which provides more accurate recognition of the structures loaded into personal datasets;
  5. My Company Datasets: it is now available within the platform for employees from the same organization to work on shared datasets (if you want to see a specific role policy in this vein - let us know);
  6. It is also now possible to create personal notes/comments on structures within personal datasets.
Improvements to the Datasets module:
The Syntelly platform can be used in the pharmaceutical, cosmetic and chemical industries, in intellectual property protection, in education, science and regulatory activities. Version 2.2 contains a number of new features and additions to enhance the ability to search, process and analyze chemical data.
Syntelly has updated its eponymous platform for searching, processing and analyzing chemical information to version 2.2. The new version includes improvements to the Datasets module, SynMap and a number of changes in the product interface that simplify its use.
Cintelli is starting to formulate a refinement plan for 2025. If you have any suggestions or comments on the platform, now is the time to share your thoughts. Email us at admin@syntelly.com.
  1. Quick structure transfer to other modules from the structure card has been implemented;
  2. Improved feedback form: added separate topics of appeals, as well as uploading files and images;
  3. Fixed rendering errors of structural formulas, and improved the quality and contrast of images;
  4. Split the synonyms block into “Titles” and “Database IDs” for easy search and browsing;
  5. SynMap module: added buttons to completely clear the map and stop generation, as well as the ability to view the generator settings after it is started.
Visual and logical refinements:
  1. Tabular analysis: You can now sort and filter structures within your own datasets by target property values before exporting;
  2. Datasets can be sorted by number of structures, by creation date and by name;
  3. The search bar has been integrated into the module: now it is possible to search both datasets and structures within each dataset;
  4. Added the ability to select an operator when loading a CSV file, which provides more accurate recognition of the structures loaded into personal datasets;
  5. My Company Datasets: it is now available within the platform for employees from the same organization to work on shared datasets (if you want to see a specific role policy in this vein - let us know);
  6. It is also now possible to create personal notes/comments on structures within personal datasets.
Improvements to the Datasets module:
The Syntelly platform can be used in the pharmaceutical, cosmetic and chemical industries, in intellectual property protection, in education, science and regulatory activities. Version 2.2 contains a number of new features and additions to enhance the ability to search, process and analyze chemical data.
Syntelly has updated its eponymous platform for searching, processing and analyzing chemical information to version 2.2. The new version includes improvements to the Datasets module, SynMap and a number of changes in the product interface that simplify its use.
1. Literature search: 160 million literature sources as well as 15 million patents have been added to the Syntelly database. Previously searchable solely by structure, it is now also possible to find related scientific publications and patents, with combined and full-text search, sorting and filtering. Text queries can be entered in Russian and English. This greatly simplifies the process of finding the necessary information among many sources;
2. Search by Markush structures: allows to easily find and analyze complex chemical structures, which saves time and efforts of users. This function is especially relevant in patent search, when the user needs to search for a group of chemical compounds;
3. updated SynMap module: added optimization and additional parameters for generation of new compounds, the quality of the generated array became much higher;
4. updated module for automatic extraction of structural formulas from documents - PDF2SMILES 2.0: the accuracy of the neural network has been improved, now it is possible to recognize Markush structures on any documents, such as patents, scientific articles, test reports and dissertations. This simplifies and speeds up the process of collecting and analyzing data for research, developing new compounds, and writing literature reviews;
5. One of the new integrations is the model applicability indicator. For each prediction, it provides an assessment of its applicability to a specific molecule, which increases the reliability of profiling new compounds and enables informed strategic planning decisions for applications in organic synthesis, medicinal and pharmaceutical chemistry;
6. New thematic datasets: datasets on molecular targets and therapeutic indications have been added to the platform. The datasets compiled by the Syntelly team may be particularly useful for educational applications;
7. Improved usability of the platform: notifications of important events on the platform have been implemented. In addition, it is possible to customize the hint system. The interface has become more intuitive and navigation is smoother;
Version 2.1 contains a number of new features and additions to enhance the ability to search and predict chemical compounds:
Syntelly's platform can be applied in the pharmaceutical, cosmetics and chemical industries, intellectual property protection, education and regulatory activities.
Syntelly has updated its eponymous platform for searching, processing and analyzing chemical information to version 2.1. The new version includes full-text literature search, Markush structures, improved modules for generating new compounds and automatic extraction of structural formulas from documents. In addition, a number of changes have been made to the product interface to simplify its use.
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